The health economy is large—roughly one in five dollars of spending in the U.S. goes toward healthcare—and constantly evolving. In recent years, government programs have created new marketplaces for health insurance and changed the pricing dynamics for pharmaceutical drugs. Private and public insurers have developed new ways to pay hospitals and physicians for the care they provide to patients. Digital health technologies, such as telemedicine, have expanded access to care in geographies far from major health facilities. The changing landscape poses both opportunities and challenges for players in the industry, from life-science companies to insurers to healthcare providers.